Global-first complete remission in Stage IVB colorectal cancer
Onco · Stage IVB pMMR/MSS colorectal cancer
- Response
- Complete remission
- Regimen
- FMT 3.0 + anti-PD-1 + anti-VEGF
- Tumor type
- pMMR / MSS
Summary
A patient with Stage IVB pMMR/MSS colorectal cancer — a subtype typically considered poorly responsive to immune-checkpoint therapy — achieved complete remission following a combination of FMT 3.0 with anti-PD-1 and anti-VEGF therapy. This is the first such case reported globally.
Why it matters
pMMR/MSS colorectal tumors are usually “cold” to immunotherapy. The outcome suggests that gut-microbiome modulation may sensitize otherwise unresponsive tumors to immune-checkpoint inhibition — a direction central to our oncology track.
Key facts
- De-identified profile: 60s, male.
- Intervention: FMT 3.0 combined with anti-PD-1 and anti-VEGF.
- Outcome: complete remission (individual result; not a guarantee of results).
Patient data de-identified. Source on file: Cureus, 2024.